Title of Journal

Article: Inflammation, Insulin Resistance, and Type 2 Diabetes

Title of Journal

Diabetes

Volume: 58.2                                          Date: 02/-/2009                Page Number(s):  Pg. 307      

·         What organization is responsible for publishing the journal you chose?

American Diabetes Association

·         What is your overall evaluation of this article?

_____Poor          ______Fair            ______Good        ___X____Very Good       _____Excellent

·         Why did you choose to review this particular article?

I chose to review this article because, 1) of its relativity to my research topic and 2) also because it struck me that something as simple as inflammation could cause diabetes.

·         How would you rate this article as a tool for teaching a student about cardiopulmonary physiology, radiography, or another allied health specialty? 

 Students:               ____Poor       ____Fair       _____Good      _____Very Good         X    Excellent Teachers:                ____Poor       ____Fair       _____Good        X    Very Good       _____Excellent Patients:                 ____Poor       ____Fair       _____Good        X    Very Good      _ ____Excellent

·         Comment on the readability of this article. 

The article is well written. The author introduces two articles that talk about inflammation. The article also displays e good use of sources well to explain his topic of choice. The article explains the topic and flows very fluently.

·         Course Topics covered:

*Using other people’s studies and findings to help answer a question or make a correlation between things.

·         Brief Summary:

The article by William T. Cefalu brings to light two different studies down on type 2 diabetes. The first study, which was done by Ortega Martinez de Victoria comments on factors related to macrophage activation in adipocytes as a source for cytokines for systemic inflammatory effects.  In contrast, a study done by Haus provides data on systemic effects resulting from inflammatory activation, namely, the relationship of cytokines with circulation lipid intermediates. Then the author gives a detailed back ground of how inflammation was recorded and discovered over 2,000 years ago by Aulus Cornelius Celsus.  Then the article discussed present day findings and how obesity, inflammation, and insulin resistance are all linked to type 2 diabetes.  Then a hypothesis for how the initiation of the inflammatory response in obesity occurs is discussed.  Then we go through the three main key points of inflammation, insulin resistance, and obesity in greater detail. The article ends by discussing relevant questions such as whether therapies that specifically target inflammation will evolve into future diabetes medications.

·         Identify and attempt to explain three (3) terms, procedures or concepts that were unfamiliar to you when reviewing this article.

1.        Rubor: redness and swelling, created by Aulus Cornelius Celsus.

2.        Microhypoxia: release of chemokines recruiting macrophages into the adipose tissue and end with the formation of crown-like structures and adipocyte death.

3.        Ortega Martinez de Victoria’s study: comments on factors related to macrophage activation in adipocytes as a source for cytokines for systemic inflammatory effect

·         Detail the strengths/weaknesses of this article.

Strengths

·         2 studies done on the same topic of interest.

·         Well written article

·         Explains in detail topics that are not commonly known

·         Goes into the past and present times to find information for the article

Weakness

·         The 2 studies done on the same topic have completely different outcomes, thus there is now a common find in either study.

·         How might this article be useful to you in your further studies and career?

The article, personally, will not help me in my future career but for someone that is doing endocrinology or specializing in diabetes, it will be very helpful. Helpful in the since that it give insight for people with inflammation. Also for people with obesity, it will be a helpful article to discuss with their doctor to see if there are any warning signs of getting diabetes if they do not already have them

·         Does the article include a list of references/citations that can be used to find more information on the topics they cover?  Yes, there is a list of references/citations that could be used to find more information on the topics covered. 

Your Name:                       Troy A. Clifton                                                 Date: 03/08/2009